الفهرس 
Enzyme inhibitionOnly 14 pages are availabe for public view
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Abstract
This work studied the effect of daily oral dose administration of cyanox in
rat on brain and Erythrocytes acetyl cholinesterase, plasma protein,
creatinine and inorganic phosphorus and also on plasma triiodothyronine
and thyroxine. The experiments were carried out over a period of 28 days.
- For this purpose, three groups of rats were used. The first one was given
1/50 LD50 of cyanox as a low dose level. The second one was given
1/20 LD50 of cyanox as a high dose level and the third one served as a
control.
Tire results revealed the (offowings:
- Administration of cyanox at the lower dose, inhibited rat brain and
erythrocytes acetylcholinesterase more than the higher dose did.
- The plasma total protein and its fractions decreased, compared to control..
- Amino transferases activities increased in plasma.
- Alkaline phosphatase enzyme was elevated in plasma in a dose-related
manner.
- Plasma creatinine level showed a significant decrease at most time intervals,
at both dose levels.
- The plasma inorganic phosphate level was elevated significantly at the two
investigated doses.
- Plasma triiodothyronine hormone increased significantly, while plasma
thyroxine hormone decreased, which means that, thyroid hormones were
inhibited due to the toxic effect of cyanox.