الفهرس 
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Abstract
Hypersplenism is a well-known complication of portal hypertension in cirrhosis that may influence
the course of the disease to favour in(ection and bleeding.
Hypersplenism is defined as the association of anaemia, leucopenia or thrombocy topeni a with norm
ocellular or hypercellular bone marrow and splenomegaly.
Partial splenic embolization has gained increasing favour as alternative to partial or total
splenectomy in the treatmen t of hypersplenism in cirrhosis.
Partial splenic embolization achieved after selectiv e catheteri zation of splenic artery and
repeated injection of gelatin in sponge until 40 - 60% reduction in splenic blood flow was
achieved, combined with sterile techniqu e and coverage with intravenou s antibiotic before
and after the
procedu re.
Th i s study w as condu cted on forty pa tien ts w i th hypersplenism · as complication of liver
cirrhosis and portal hypertension.
All patients were subjected to :
A) Full history taking and thorough clinical examination.
B) Laboratory investigations :
1. Complete blood picture before and after partial splenic
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embolization.
2. Liver fu nction tests includi ng (bilirubin [total and direct], serum transaminases [AST and
ALT], serum albumin and prothrombin concentration).
3. Kidney function tests (Blood urea, serum creatinine).
4. Viral markers (HBsAg, HCV-Ab).
5. Bone marrow aspiration.
6. Sigmoidoscopy and rectal snips.
C) Liver biopsy whenever possible.
D) Upper gastrointestinal endoscopy.
E) Abdominal ultrasound and duplex Doppler.
F) Angiograph y.
The results of this study showed :
1 . Si gnificant and sustained increase in platelets and leucocytic count.
2. Significant increase in haemoglobin percentage and red blood cell count, but did not reach
the normal v alues.
3. No significant change in liver function tests. 4. No significant change in grading of esophageal varices.
5. There was significant decrease in portal vein diameter and size of spleen.
6. No serious complications were reported. The results of our
•
study showed that partial splenic embolization when
perform ed correctly is safe and usefu l altern ative to splenectomy in patient with cirrhosis and
hypersplenism caused by portal hypertension .