الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Heavy menstrual bleeding (HMB) is a common clinical problem, as approximately 30% of women complain of HMB sometime during their childbearing period. The clinical investigation usually focuses on organic pathologies affecting the uterus itself. However, in approximately 50% of cases, no organic pathology is determined, and dysfunctional uterine bleeding DUB is diagnosed. Many studies revealed that many women with a normal gynaecological examination complaining of HMB have an underlying haemostatic disorder. The prevalence of von Willebrand disease (VWD) in such women was reported to be 5–20% of cases. Platelet function defects are also common in women with unexplained menorrhagia. It is thus suggested that in women presenting with menorrhagia, screening tests for haemostasis, especially for platelet function defects and vWD must be performed.
The aim of this work was to estimate the frequency of von Willebrand disease and other bleeding disorders among women with menorrhagia.
Our study was conducted on 20 patients complaining of menorrhagia attending Alexandria University Main Hospitals at El Shatbi and El Miri compared to 20 apparently healthy females with matched age.
All subjects were subjected to thorough history taking including personal history, family history of bleeding manifestations, menstrual history and drug history, clinical examination and laboratory investigations.
Laboratory investigations included complete blood count, blood group typing, prothombin time, activated partial thromboplastin time, Factor VIII assay, ristocetin cofactor activity using agglutination method and platelet function testing using whole blood aggregometer.
Our results were 55 % of the cases were characterized to have an inherited bleeding disorder. Platelet function defects were found to be more common then coagulation defects.
We can conclude that hemostatic defects are common among women who complain of heavy menstrual bleeding. Laboratory investigations of such disorders should be incorporated into the