الفهرس 
Cardiac TroponinsOnly 14 pages are availabe for public view
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Abstract
I
mpaired uteroplacental blood flow in pre-eclamptic pregnancies may result in the development of functional and structural anomalies in many fetal organs due to intrauterine hypoxia. Fetal myocardium is also affected.
Cardiac troponin T (cTnT), a cardiac structural protein, is regarded as a highly specific and sensitive marker of myocardial damage.
This study aimed to investigate the relationship of cord blood cardiac troponin T levels in apparently clinically well preterm neonates of preeclamptic mothers and their cardiac functions measured by echocardiography.
The study included 70 preterm neonates (G.A.= 29-36 weeks) that were divided into two groups:
group (1): The study group:
It included 35 preterm neonates of pre-eclamptic mothers (mainly of mild pre-eclamptic mothers).
group (2): The control group:
It included 35 preterm neonates of mothers who are not preeclamptic.
Preterm neonates were excluded from the study when they had one of the following:
1- Major congenital anomalies.
2- Chromosomal aberrations.
3- Evidence of prenatal maternal infection.
4- Maternal systemic diseases as diabetes mellitus, chronic renal disease, cardiac disease and chronic hypertension.
5- Critically ill preterm neonates whether ventilated or not.
Both groups were subjected to complete history taking, thorough clinical examination, gestational age assessment, recorded Apgar scores at 1 min. and 5 min., birth weight measurement and determination if small for gestational age (SGA) or appropriate for gestational age (AGA). CBC and CRP were done at birth. Cardiac troponin T level was measured in the cord blood by Chemiluminescence immunoassay technique.
Our results showed statistically significant higher gestational age and birth weight of the study group when compared to control group.
Our results revealed that there was no statistically significant difference between study group and control group as regards sex and Apgar scores at 1 and 5 minutes.
Our results revealed non-statistical significant difference between study group and control group as regards the weight for gestational age and mode of delivery.
Our results also showed that the study group had highly statistically significant lower total leukocytic count and platelet count when compared to the control group.
Our results revealed that the study group had statistically significant higher hemoglobin level when compared to the control group.
Our results revealed non-statistical significant difference between study group and control group as regards to CRP concentration.
The results showed that the study group had highly statistically significant higher level of cardiac troponin T when compared to control group.
Our results also showed that there was no statistically significant difference between study group and control group as regards systolic blood pressure, diastolic blood pressure and heart rate.
Our results also showed that there was significant positive correlation between cardiac troponin T and heart rate in the study group.
Our results revealed that there was significant negative correlation between cardiac troponin T and hemoglobin level in the study group.
Our results also revealed that there was significant positive correlation between cardiac troponin T and mitral E-wave in the study group.
The results showed that there was highly significant positive correlation between cardiac troponin T and MV E/A ratio.
Our results also revealed that there was no statistically significant difference between normal and abnormal cardiac troponin T groups as regards to gestational age, birth weight and Apgar scores at 1 minute and 5 minutes.
The results showed that there was no statistically significant difference between normal and abnormal cardiac troponin T groups as regards sex, mode of delivery, weight for gestational age and laboratory parameters.
Our results also revealed that there was no statistically significant difference between normal and abnormal cardiac troponin T groups as regards systolic blood pressure, diastolic blood pressure and heart rate during first day of life.
Our results revealed that there was no statistically significant difference between normal and abnormal cardiac troponin T groups as regards to echo parameters.