الفهرس 
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Abstract
Asthma is a worldwide problem with an estimated 300 million affected individuals. The prevalence of asthma is increasing, especially in children and it is the most common chronic disease of childhood in industrialized countries. There is a lot of evidence showing that platelets play a role in both allergic and nonallergic inflammatory conditions.
Leptin is a protein mediator secreted by adipocytes and macrophages within the adipose tissue and it is also usually pro-inflammatory. Leptin has therefore been suggested to belong to the relation between obesity and asthma.
The present study is a comparative one carried out at the child outpatient chest clinic of Minia University Hospital during period from June 2013 to September 2013. The study included 75 child divided as (25 cases diagnosed as mild asthma, 25 cases diagnosed as moderate asthma and 25 child as healthy controls). The aim of the study was to evaluate the role of serum leptin and the change of mean platelet volume values as inflammatory markers in asthmatic children. The 75 cases were divided into 3 groups as follow:
group (I): Mild asthma.
group (II): Moderate asthma..
group (III): Controls.
The results could be summarized as follow:
Our study reveals higher significant difference regarding leptin hormone in asthmatics than controls.
Our study indicated that no significant differences among groups in the MPV concentration.
As regard to (RDW) control group had significantly higher level than the asthmatic group.
We found no significant difference between studied groups as regarding to platelet count.