الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The thesis consists of four chapters: Chapter 1: General introduction about
gastric ulcer, indomethacin-induced gastric ulcer provides a relevant example
of endogenous acute oxidative stress and ulcer, antioxidant, medicinal plant,
kiwifruit and diseases. Chapter 2: This study evaluated the stomach oxidative
stress induced by indomethacin in rats with consequent changes in endogenous
(enzymes and non enzymes) antioxidant, oxidative damage to protein, lipid,
DNA, and examined the potential role of kiwifruit against the changes
indomethacin induced. 40 male albino rats were used in this study, divided into
four groups (control, kiwifruit, indomethacin and treated groups). Biochemical
parameters, (histopathological and histochemical) examination were estimated.
Liver enzymes (serum aspartate transaminase, serum alanine transaminase),
kidney functions (serum creatinine, blood urea), oxidant and antioxidant
parameters (stomach total antioxidant capacity, stomach superoxide dismutase,
stomach malondialdehyde), serum vitamin A, serum vitamin E, serum
interleukin -1α, comet assay (DNA damage) were estimated. Chapter 3:
Administration of kiwifruit extract showed an inhibition in indomethacin
induced gastric ulceration. In treated group of animals, the in vivo antioxidant
levels such as total antioxidant capacity, stomach superoxide dismutase levels
were increased. The tissue lipid peroxidation level, serum interleukin -1α, DNA
damage were decreased. Histopathological examination of rat stomachs
kiwifruit extract induced reduction of the depth and severity of indomethacininduced
mucosal lesions. The powerful effect of kiwifruit may be attributed to
their potential to remove free radicals through their phenolics which can donate
electrons to H2O2 and neutralize it to water. Chapter 4: It was concluded that
kiwifruit seems to be a heighly promising agent in protecting against
indomethacin induced gastric ulcer.