الفهرس 
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Abstract
The present thesis describes the preparation and investigation of performance characteristics of ion-selective electrodes for the antidepressant drug, paroxetine hydrochloride. The electrodes are of the PVC membrane, coated wires electrode, and chemically modified carbon paste types. The active recognition in the electrodes is liquid ion exchange mechanism depending upon ion-exchanger which is ion-associate of the Prx+ with tetraphenylborate, phosphotungstate, and phosphomolybdate incorporated in the membrane.
The thesis comprises four chapters:
Chapter (I), Gives a general introduction on the various electroanalytical techniques and their application. The chapter gives an idea about the different types of chemical sensors and discusses in detail electrochemical sensors. It also gives a brief review of the important potentiometric sensors developed for different drugs.
Chapter (II), This chapter comprises a literature survey on the different methods used for determination of paroxetine hydrochloride. These include chromatographic, spectral, and electrometric methods. from this literature survey it was obvious that there has not been any report on the development of selective electrodes for the investigated drug.
Chapter (III): Deals with the development of three novel e1ectrochemical sensors for the determination of the drug paroxetine hydrochloride (Prx.Cl) based on Prx-TPB (paroxetine tetraphenylborate) ion-pair as the electroactive material. The electrochemical response characteristics are described in detail and the application study of the developed sensors in the determination of the drug in pharmaceuticals, urine and plasma samples have also been dealt with in detail.
Chapter (IV), Presents the fabrication of PVC membrane and coated wire electrodes for paroxetine hydrochloride based on the ion associations of the drug with phosphomolybdic acid (PMA), and phosphotungstic acid (PTA) as forming agents. The sensors exhibited stable, fast Nernstian response over a wide concentration range. The developed sensors have also been used for the determination of the drug in pharmaceutical preparations and also for the determination of the drug in plasma and urine samples
Chapter (V), Describes the fabrication of two carbon paste sensors for the quantitative determination of paroxetine hydrochloride. The sensors incorporate the ion-associates of the drug with phosphomolybdic acid and phosphotungstic acid as electroactive materials. The analytical applications of the developed sensors in the determination of the drug in pharmaceutical formulations and biological fluids like urine and plasma were also investigated.
ABSTRACT
Title of the Ph.D. Thesis:
New Sensors for Determination of Paroxetine Hydrochloride
Name of the candidate:
Ali Gaber Mohamed Ali
Degree: Ph.D. Faculty of Science, Beni-Suef University
The studies presented in this thesis describe the preparation and investigation of performance characteristics of new polymeric membrane, coated wire and modified carbon paste electrodes for the determination of Paroxetine hydrochloride. The electrodes are based on ion-associates formed from the associations of the drug cation with anions of tetraphenylborate, phosphotungstate, and phosphomolybdate. The electrodes were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range and temperature. The proposed electrodes were successfully applied for the determination of paroxetine cation in bulk powder, pharmaceutical formulation, and biological fluids (urine and plasma) and as indicator electrodes in potentiometric titration of paroxetine cation.
Keywords: Paroxetine hydrochloride; potentiometry, polymeric membrane electrode; coated wire electrode; carbon paste electrode; pharmaceutical formulations; biological fluids.