الفهرس 
chapter 1Only 14 pages are availabe for public view
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Abstract
towards Ehrlish ascites carcinoma (EAC) cells by reductiob of its volum to 44.44% and 62.22% (p ≤0.001), in the treated group; respectively. And significantly decrease in the cell count by 55.05% and 60.76% in treated groups (p≤0.001);respectively, compared to the control group.
It turned out that they reduced cell viability of cancer cells in a time and concentration dependent manner in vitro and in vivo studies. The synthesized compound have potent antioxidant activity and good inducer for apoptosis by induction of P53.
The apoptotic effect of compounds 3a and 4b were evaluated by measuring of tumor suppressor p53 intensity in all studied group.
Furthermore, the treatments with 3a and 4b (7.5 mg/kg, and 10mg/kg, IP.) showed a significantly increase in P53 intensity, compared to the positive control group.
It turned out that they reduced cell viability of cancer cells in time and concentration dependent manner in vitro and in vivo studies. The synthesized compound have potent antioxidant activity and good inducer for apoptosis by induction of p53 and releasing of caspases as antitumor and antioxidant effects of compound 4b more than compound 3a due to second thiosemicarbazone moiety on pyridine ring.