الفهرس 
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Abstract
Perinatal asphyxia (PA) is an insult to the fetus or the newborn due to lack of oxygen (hypoxia) and/or lack of perfusion (ischemia) to various organs of sufficient magnitude and duration to produce more than fleeting functional and/or biochemical changes.
Perinatal asphyxia and the resultant hypoxic ischemic encephalopathy (HIE) remain a leading cause of morbidity and mortality in the perinatal period in Third-World countries.
The World Health Organization (WHO) estimates that globally, between four and nine million newborns suffer birth asphyxia each year.
The aim of this study was to assess cord blood malondialdehyde, in addition to urinary malondialdehyde, uric acid and protein levels in neonates with perinatal asphyxia and their relationship to the severity of perinatal asphyxia.
This study was conducted on a group of 20 term AGA (appropriate for gestational age) neonates with perinatal asphyxia (16 males and 4 females) were selected as cases and the same number of healthy neonates (11 males and 9 females) as controls.
The study was carried out inside the gynecology & obstetrics department and the neonatal intensive care units (NICU), in Qous central hospital, Qena.The laboratory test was done in Qena university hospital, clinical pathology department in the period from June 2012 to October 2012.
In this study we found that Cord blood malondialdehyde concentration in asphyxiated neonates was significantly higher when compared to healthy non-asphyxiated ones, representing a diagnostic marker of oxidative stress.
The excretion rates of urinary uric acid, protein and MDA to creatinine ratios increase with the severity of perinatal asphyxia and associated brain damage and hence these parameters have potential as severity evaluation and prognostic markers.