الفهرس 
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Abstract
Background : Epilepsy is defined as a brain disorder characterized by an enduring predisposition to generate epileptic seizures and by the psychologic, cognitive, and social sequelae of this condition. It was suggested that the reproductive disorders that occur in epileptic females could be attributed to epilepsy itself rather than to AEDs. This might take place via spreading of generalized paroxysmal activity into the areas of the hypothalamus that regulate the pituitary gonadotropins which keep normally menstrual cyclicity. AED, and especially valproate (hepatic enzyme inhibitor), have been associated with reproductive endocrine disorders particularly features of polycystic ovary syndrome (e.g., irregular menstrual cycles, weight gain, and hirsutism).
Aim: The aim of this study is to investigate the effect of valproate on the physical growth, pubertal development, and androgenic status of girls with idiopathic epilepsy.
Patients and Methods: This study included 50 adolescent females were classified into two groups: Patient group: included thirty adolescent female patients with idiopathic epilepsy, Control group: Included twenty age matched adolescent female.
Results: Demographic characteristics among the studied women in both groups show that BMI was higher in our study group when compared to control group but not reaching the significant level. there was significant decrease of FSH, LH and E2 in study group when compared to control group. On the other hand, there was significant increase of total testosterone in study group when compared to control group (2.85±0.81 vs 0.88±0.20 respectively), and there is a positive correlation between the duration of therapy and testosterone level.
Conclusions: Treatment of adolescent girls with VPA may be associated with higher incidence of reproductive endocrine disorders in the form of delayed pubertal maturation and menstrual irregularity. It also associated with higher incidence of androgen excess in the form of hirsutism and acne.