الفهرس 
Chronic Myelogenous LeukemiaOnly 14 pages are availabe for public view
 |  | from | 226 |  |  |
| | | from | 226 | | |
Abstract
CML is a haematopoietic stem cell disease, which characterized by a reciprocal translocation between chromosome 9 and 22, resulting in formation of the Philadelphia chromosome (ph chromosome). Tyrosine kinase inhibitors have proven particularly efficient in the treatment of CML. Nevertheless, MTTS can inhibit major pathways in normal or cancerous cell leading to unexpected off-target side effects, morbidity, reduced drug doses, or even drug cessation. Hypertension is one of the complications of TKIs, treatment with TKIs that target vascular endothelial growth factor (VEGF) is associated with hypertension that can be life-threatening and cause damage to eyes, brain, or kidneys.
Left ventricular systolic dysfunction and heart failure is a second complication. While, diagnosis of heart failure based on clinical and physical examination remains difficult in daily clinical practice. Q-T interval prolongation has garnered attention because of its risk of malignant arrhythmia with torsade de pointe sudden cardiac death