الفهرس 
hmnune responseOnly 14 pages are availabe for public view
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Abstract
Spleen represents the meeting point between antigenic
information transported by blood stream and immune apparatus responsi ble for mounting the host
response ( Lokwood, 1983).
The spleen makes up to 25% of the total lymphoid mass and is an important component of the reticu
loendothelial system (Ellison et al., 1983 ) .
Aim of the work
Is to study the immune profi le in patients with chronic liver disease and portal hypertension
after total splenectomy
Patients and Methods
In this study, ten patients with portal hypertension were subjected to elective splenectomy.
Haematological profile and imm unological profile (lgM, IgG, lgA, CD4, CDS, CD19, CD3, and
CD4/CD8) was done before and one month after
splenectmy. Immunological profile for ten normal control was measured .
Results
Splenectomy in portal hypertension improve all blood elements counts but decrease patient
cellular immunity in form
of decrease total T lymphocyte, T helper and increase T suppressor and decrease ratio .