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Abstract Objective To study the utility of DWI and ADC in increasing the specificity of MRI in differentiating benign from malignant solid breast lesions Patients and methods 20 female patients were included in our study. All patients referred to MRI unit -Radiology department –Ain Shams University hospitals to do bilateral breast MRI using conventional sequences ,DWI ,ADC calculation and post contrast dynamic study with time /intensity curve using Philips super conductive magnet at 1.5 T with breast coil. All the patients were subjected to clinical examination , sonomammography as well as written consent also the histopathological results were recorded Results 20 lesions were detected , 12 were malignant and the rest lesions were benign . The sensitivity of DWI was 83.33% while the specificity 87.50%. The ADC values for the benign lesion were 1.3-2.2x10-3mm2/sec, while the malignant lesions showed the ADC values of 0.4-0.97x10-3mm2/sec. The ADC value of 1.0 x10-3mm2/sec can be used as the cut off value in differentiating the benign from malignant lesions. Conclusion DWI and ADC calculation are short unenhanced sequence that can be inserted easily in to MRI protocols to accurately differentiate between the benign and malignant breast lesions |