الفهرس 
Publication
Benign prostatic hyperplasia (BPH)Only 14 pages are availabe for public view
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Abstract
The model of CLP-induced acute lung and liver inflammation : CLP increased percentage of mortality and heart rate and decreased rectal temperature and respiratory rate. CLP elevated total and differential cell count, total protein, LDH activity, ALT, AST, ALP, γ-GT, total bilirubin and abnormalities in lung and liver structure in histological section. Furthermore, PMN trafficking activity was increased as indicated by histopathological examination, in addition to elevated MPO activity in lung and liver tissues. Moreover, CLP activated TLR4/NF-κB pathway and subsequently increased TNF α level in addition to prominent oxidative stress reflected by increased MDA content, decreased GSH level and SOD activity. Additionally, CLP decreased contractile response of PA to KCl and PE and relaxation response to ACh but not to SNP. Pretreatment with POM improved survival and attenuated lung and liver inflammatory response in CLP model by inhibiting TLR4 expression, NF-κB p65 activation and associated cytokines release such as TNF α. Additionally, PMN trafficking activity and prominent oxidative stress induced by CLP were attenuated by POM pretreatment. Moreover, POM improved CLP-induced impairment in contraction response to KCl and PE and relaxation response to ACh reflecting its potential to have protective role in CLP-induced acute lung and liver injury. The model of I/R-induced acute kidney injury: I/R increased creatinine, AST, K+, urea nitrogen, CRP in serum and leukocytes count, glucose and microalbumin in urine and decreased creatinine clearance. Furthermore, PMN trafficking activity was increased as indicated by histopathological examination, in addition to elevated MPO activity in kidney tissues. Moreover, I/R decreased IκB α mRNA expression and subsequently increased NF-κB p65 nuclear expression and DNA binding activity and TNF α mRNA and protein expression. I/R also caused prominent oxidative stress reflected by increased MDA content, decreased GSH level and SOD activity. Pretreatment with POM days prior to I/R improved kidney function parameters and histological changes in rats. Moreover, POM pretreatment markedly decreased the elevated MPO activity and mRNA expression, TNF α protein and mRNA expression, p65 protein expression and DNA binding activity and elevated the decreased IκB α mRNA expression caused by I/R. Additionally, POM pretreatment reduced I/R induced prominent oxidative stress. These changes match to histopathological examination showing a marked decrease inI/R induced inflammatory cells infiltration, medullary congestion and hemorrhage and obstructing casts in medulla. Part II: Clinical part. In this part, we investigated the efficacy of POM on LUTS related to BPH patients. 60 patients suffering from LUTS secondary to BPH were randomly divided into two equal groups; placebo group (30 patients) and pomegranate group (30 patients). In placebo group, I-PSS was significantly improved. On the other hand, QOL, Qmax, Qave, PVR and PSA were not significantly different when compared to baseline reading. In POM group, I-PSS, QOL, Qmax, Qave and PVR were significantly improved when compared to pre-treatment values in the same group and post-treatment values in placebo group. On the other hand, PSA level was significantly decreased when compared to baseline reading in POM group but it was not significantly different from post-treatment value in placebo.