الفهرس 
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Abstract
endritic cells are professional APCs of the immune system, specialized for the uptake, processing, transport and presentation of antigens to T cells with a unique capacity to activate naı¨ve and memory T cells. They exert important functions both in induction of T cell immunity, as well as tolerance. It is well established that the main function of iDC in their in vivo steady-state condition is to maintain peripheral tolerance to self-antigens and that these iDC mature upon encounter of danger signals and subsequently promote T cell immunity. T cell unresponsiveness induced after stimulation with iDC is caused by the absence of inflammatory signals in steady-state in vivo conditions and by the low expression levels of costimulatory molecules on iDC. In addition to the fact that iDC can also actively maintain peripheral T cell tolerance by the induction and/or stimulation of regulatory T cell populations.