الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Aging is a universal, intrinsic, progressive and deleterious process, it is generally characterized by the increasing homeostatic imbalance and increased risk of aging-associated diseases. Most common are type 2 diabetes mellitus, arthritis, Alzheimer’s disease, osteoporosis, cancer and cardiovascular diseases (mainly atherosclerosis). The first structural change that can be detected in atherosclerosis is an increase in CIMT.
Adipose tissue synthesizes and secretes various adipokines, such as adiponectin and leptin.
Adiponectin is a kind of circulating adipokine that inhibit pro-atherogenic process, the exact mechanism is yet to be elucidated but may include enhancing endothelial nitric oxide synthase activity, inhibiting inflammatory changes that lead to increased expression of endothelial adhesion molecules, suppression of macrophage activation required for development of foam cells. These pathophysiologic actions of adiponectin have led many authors to suggest that it may play a protective role against atherosclerosis and cardiovascular risk.
This study was designed to assess serum Adiponectin as a biomarker for atherosclerosis; and its relation to the carotid intima-media thickness as a clinical surrogate marker of atherosclerosis in elderly patients.
The study was conducted on 80 (eighty) subjects aged 20-85ys subdivided into 4 groups. The first group is the control (GI) which included 20 healthy young volunteers aged 20 – 40 years old of normal BW and BMI as well as arterial blood pressure measurement. The other three groups included 20 elderly subjects aged >65 years and each classified according to arterial blood pressure and serum blood glucose into elderly healthy (GII) elderly hypertensive (GIII) and elderly diabetics (GIV).
The present study conducted on elderly subjects (age > 65) the serum adiponectin concentrations were measured by a radioimmunoassay.
The adiponectin level was correlated negatively with age, CIMT, waist circumference, body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, LDL cholesterol, glucose, and correlated positively with HDL cholesterol. The duration and control of diseases (DM, HTN) affecting serum adiponectin level negatively.
In conclusion, adiponectin was significantly negatively correlated with CIMT.