الفهرس 
Aim and plan of the workOnly 14 pages are availabe for public view
 |  | from | 192 |  |  |
| | | from | 192 | | |
Abstract
The master thesis include aim of the work and Three main chapter
I- Aim of the work
The work aimed to prepare and characterize new hydroxy
hydrazone ligand and its metal complexes aiming to study
their effects in the treatment of tumor diseases.
II- Introduction
This chapter includes an overview of previous researches for
complexes of hydrazone ligands and their application.
III- Experimental
This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of the hydrazone ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic
susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of biological activity
II
iv. Results and discussion
This chapter includes characterization of the ligand and its complexes.
The ligand 2-((E)-(2-((Z)-1,2-bis (phenylamino) vinyl) hydrazono)
methyl)naphthalen-1-ol was prepared as follow:
1- Condensation of aniline with of ethylchloroacetate (2:1) for one
hour to obtain 1, 2-bis (phenylamino)ethenol.
2- Condensation of 1,2-bis (phenylamino) ethanol with of
hydrazinehydrate for two hours to obtain 1-hydrazinyl-N1,N2-
diphenylethene-1,2-diamine.
3- Reaction of 1-hydrazinyl-N1,N2-diphenylethene-1,2-diamine with
of naphthaldhyde with stirring for thirty minutes to obtain 2-((E)-(2-
((Z)-1,2-bis(phenylamino) vinyl) hydrazono)methyl)naphthalen-1-ol..
The reaction of the ligand with Cu(II), Ni(II), Mn(II), Fe(III), Co(II),
Zn(II), Cd(II), Pb(II), Sr(II), and Tl(I) complexes have been synthesized
and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy,
(magnetic moments, conductance) measurements, (elemental and
thermal) analyses. The IR spectral data show that, the Schiff base behaves
as a neutral bidentate or monobasic bidentate ligand bonded to the metal
ions through the azomethine nitrogen atom and hydroxyl oxygen atom in
protonated or deprotonated form adopting either octahedral or
tetragonally distorted octahedral geometries. Molar conductance in DMF
solution indicates that, the complexes are non-electrolytes. The ESR
spectra of solid Cu(II) complexes (2,3) show an axial type indicating a
d(X
2
-y
2
) or d(Z
2
) ground state with a significant covalent bond character.
However, Co(II) complexes (4,5), Fe(II) complex (6) and Mn(II)
complexes (7), show isotropic type indicating an octahedral geometry.
Cytotoxic evolution of the ligand and its complexes have been carried out. Complexes show enhanced activity in comparison to the parent
ligand. Metal complexes (2), (5), (11), (15) and (18) were evaluated
against HEPG-2 cell line and Metal complexes (3), (13), (14) and (16)
were evaluated against A-549 cell line showed good chemotherapeutic
effect.