الفهرس 
Histological and physiological OverviewOnly 14 pages are availabe for public view
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Abstract
Gliomas which originate from neural stromal cells are the most common and malignant brain tumor. Human gliomas account for average, 44.69%of central nervous system tumors. The five-year survival rate is between 20% and 30%. Due to the tumor’s infiltrating growth and no evident boundary with the normal brain tissue, it is difficult to be removed completely via surgery. In addition, gliomas are not susceptible to radiotherapy or chemotherapy, which makes it the worst prognoses in systemic tumors. Therefore, it is urgently needed to identify the critical carcinogenic pathways and discover novel treatment strategies for glioma. Gliomas are classified into four clinical grades (I–IV) on the basis of tumor histopathology according to the World Health Organization (WHO). Grade I glioma is usually regarded as relatively benign lesions. Grades II, III, and IV gliomas have an infiltrative and aggressive phenotype. The growth and proliferation of glioma cells are highly dependent on angiogenesis. The glioma has a strong ability in promoting the formation of angiogenesis and microvascular network to provide the tumor with nutrients for the sake of further invasion and metastasis. So the treatment of antiangiogenesis therapy has become an important method in.