الفهرس 
Warfarin mechanism of actionOnly 14 pages are availabe for public view
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Abstract
Mohamed Said Abu Elkheir
M.Sc., Fac.Sci.Ain Shams Univ., Cairo, 2016
Hematological and Pathological Studies on the
Effect of Warfarin in Adult Male Albino Rats.
Keywords: warfarin , prothrombin time , total oxidant status
, glutathione, liver, spleen , kidney.
The current study was designed to examine the effect of
different doses of warfarin (0.03 and 0.06 mg/100g b.wt ) on
haematological, biochemical parameters and there correlation
with pathological changes in liver, kidney and spleen in male
albino rats .
Oral warfarin administration led to a significant prolongation
of prothrombin time , partial thromboplastin time as well as,
elevation of the levels of total oxidant status, total nitric
oxide, aspartate aminotransferase and alanin
aminotransferase. However warfarin administration showed a
significant decrease in the levels of blood viscosity, red
blood cell osmotic fragility, total antioxidant status, reduced
glutathione and oxidized glutathione.
Warfarin showed non significant change in the levels of
protein C , protein S, serum triglycerides, cholesterol, high
density lipoprotein, low density lipoprotein, , creatine kinase,
lactate dehydrogenase.
In correlation with biochemical and haematological results,
warfarin showed changes in the examined organs (liver,
spleen and kidney).