الفهرس 
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Abstract
Rats administrated with sodium benzoate elucidated dilatation and congestion in the central vein and vacuolation in hepatocytes. Kidney showed shrinkage of Malpighian corpuscles, glomerular destruction, tubular degeneration and hemorrhage.
We concluded that tartrazine, monosodium glutamate, sunset yellow, and sodium benzoate adversely affect and alter different biochemical parameters, especially those related to vital organs e.g. liver and kidney and that sunset yellow has the least adverse effects in comparison with the other food additives. Also, there is a gradation in the toxic side effects of the studied food additives on the normal histological architecture of vital organs (liver and kidney). Monosodium glutamate had the most severe side effects, followed by tartrazine and sodium benzoate, but the least side effects were observed in sunset yellow group.
Unfortunately, food additives are being used in all the ready-to-serve foods without minding the possible adverse effects from its slow and gradual accumulation over time at low concentrations, especially on children and vulnerable people. Upon previous studies, and the findings of our study, it is recommended to limit the use of food products containing the previously mentioned food additives, especially those containing monosodium glutamate and tartrazine in order to preserve public health.