الفهرس 
Chemical and Biological Reactivity of Some Substituted Quinolinones
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Abstract
Chemical and Biological Reactivity of Some Substituted Quinolinones
Al-Shimaa Badran Abdel-Monem
Department of Chemistry, Faculty of Education, Ain Shams University
Treatment of α,γ-diketo ester 2 with some nitrogen nucleophiles such
as 1,2-, 1,3-, and 1,4-binucleophiles gave new members of fused and/or
isolated heterocyclic derivatives of quinolin-2-one family of expected
biological activity. The reactivity of α,γ-diketo ester 2 towards malononitrile
as carbon nucleophile was investigated under different reaction conditions.
Also, chemical behavior of α,γ-diketo ester 2 towards different electrophilic
reactions such as nitration, halogenation and condensation reactions was
studied out to afford novel quinolinone derivatives, bearing different
substituents. Structures of the newly synthesized products have been deduced
on the basis of their elemental and spectral analyses. New substituted
quinolones were screened for their biological activities in which some
products indicated antioxidant and anti-cancer activities.
Keywords: Quinolinone, Claisen reaction, Nucleophilic reactions,
Electrophilic substitution, Heterocyclization, Biological applications.
Supervisors:
Prof. Dr. Mohamed Abass Mohamed ………………………….
Professor of Organic Chemistry, Faculty of Education, Ain Shams University.
Prof. Dr. Manal Mohamed Ramadan …………………….
Professor of Biochemistry, Head of Flavour and Aromatic Chemistry
Department, National Center of Research
Assist. prof. Dr. Magdy Ahmed Mohamed ………………………….
Assist. Professor of Organic Chemistry, Faculty of Education, Ain Shams
University.
Assist. prof. Dr. Hany Mohamed Hassanin ………………………….
Assist. Professor of Organic Chemistry, Faculty of Education, Ain Shams
University.