الفهرس 
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Abstract
Bronchiolitis is an acute, inflammatory respiratory illness of
infants in the first two years of life with an incidence peak between 3
and 6 months of age and a major cause of hospitalization in that age
group. (DeNicola, 2012).
Now it is clear that vitamin D has extensive
immunomodulatory effects. It is well known that the active vitamin
D generating enzyme, 1α-hydroxylase, is expressed by the airway
epithelium, alveolar macrophages, dendritic cells and lymphocytes
indicating that active vitamin D can be produced locally within the
lungs. (Hansdottir et al., 2010).
25(OH) D is the major circulating form of vitamin D; thus, the
total serum 25(OH)D level is currently considered the best indicator
of body vitamin D status and vitamin D supply to the body from
cutaneous synthesis and nutritional intake. (Nguyen et al., 2013).
Immunoglobulin E mediates Type 1 allergic reactions that play
a role in the pathogenesis of bronchiolitis. (DeNicola et al., 2012).
In the present study we aimed to estimate serum 25(OH)
vitamin D and serum immunoglobulin E in infants with bronchiolitis
and to find the relation between serum 25(OH) vitamin D and serum
immunoglobulin E, based on the hypothesis that vitamin D
deficiency plays a role in bronchiolitis.
Our study included 50 infants with bronchiolitis; group I
(cases). Their age ranged from 2 months to 2 years. The mean age
for cases was 7.2+3.3 months. Among the total number of studied
cases 31 (62%) were males and 19(38%) were females.