الفهرس 
Polycystic Ovary Syndrome (PCOS)Only 14 pages are availabe for public view
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Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS produces symptoms in approximately 5 to 10% of women of reproductive age (12–45 years old) and is thought to be one of the leading causes of the female subfertility.
Aims: The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with PCOS.
Methodology: Type of study: Randomized controlled trial study; Site of study: Maternity hospital of Ain Shams University. Duration of study: Six months from August 2015 – February 2016. Study population: One hundred and eighty six patients were assessed for eligibility. Twenty patients were excluded during the duration of the study. One hundred and sixty six patients with PCOS who got pregnant after the administration of Metformin divided on 2 groups, each group included 83 patients.
Results: One hundred and sixty six pregnant women with criteria of PCO and receiving preconception Metformin were divided randomly on 2 sub groups as follows: group (A): 83 patients stopped metformin at diagnosis of pregnancy (5-6 weeks gestation calculated from 1st day of a reliable LMP). group (B): 83 patients continued metformin until end of 1st trimester (14 weeks gestation calculated from 1st day of a reliable LMP)
Conclusion: In conclusion, the continued use of metformin in pregnant women with PCOS during 1st trimester was associated with a significant reduction in the rates of early pregnancy loss. It was well tolerated by patients with a minimum of side effects. However, extended studies are required to evaluate its effect on further pregnancy complications and fetal outcomes.
Recommendations: Based on this study, Metformin is recommended to be used in PCO patients during induction of ovulation and continued during 1st trimester of pregnancy. Further studies are recommended to study the effect of metformin all through pregnancy and notice its effect on other complications during 2nd and 3rd trimester.