الفهرس | Only 14 pages are availabe for public view |
Abstract Aspirin, is a nonsteroidal anti-inflammatory drug (NSAID) used in various pathological conditions for its anti-inflammatory, antipyretic, and analgesic benefits. The present study was designed to evaluate the influence of long term administration of aspirin, either in low or high dose, on spermatogenesis, reproductive hormones, and oxidant /antioxidant status of testicular tissue. After one week of acclimatization, rats were weighed and randomly allocated into 3 equal groups, each of 16 rats as illustrated in table (1). group 1: Rats received 0.5 ml distilled water for 60 days. group 2: Rats Received aspirin at dose of (5 mg kg-1 b.w.) orally twice daily for 60 days. group 3: Rats Received aspirin at dose of (125 mg kg-1 b.w..) orally twice daily for 60 days. Rats were fasted overnight. Five rats from each group were weighed then sacrificed via jugular vein section under light ether anesthesia on 30 days and 60 days of experimental period. Then samples were taken to evaluate hematological parameters, oxidant/antioxidant status, spermogram and histopathological finding. And our results were as following: VIII.Effect of aspirin on total body weight, body weight gain. Oral administration of both doses of aspirin for 30 and 60 successive days induce a significant decrease in body weight and body weight gain compared with the control group. IX.Effect of aspirin on hematological parameters. Aspirin administration at different doses for 30 successive days induced a non-significant decrease in RBCs count compared with the control group. However, continuous administration of both doses of aspirin for successive 60. |