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العنوان
Effect of Some Analgesics (Aspirin) on Male fertility and Antioxidant Enzymes Activities /
المؤلف
Hassan, Mohamed Mamdouh Abdelhamid.
هيئة الاعداد
باحث / محمد ممدوح عبدالحميد حسن
مشرف / حسنى عبدالفضيل ابراهيم حسن
مشرف / عزة احمد عبدالغفار جلال
مناقش / السيد كامل متولى
الموضوع
Aspirin- pharmacology. Antioxidants.
تاريخ النشر
2016.
عدد الصفحات
115 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة الزقازيق - كلية الطب البيطرى - Pharmacology
الفهرس
Only 14 pages are availabe for public view

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from 136

Abstract

Aspirin, is a nonsteroidal anti-inflammatory drug (NSAID) used in
various pathological conditions for its anti-inflammatory, antipyretic, and
analgesic benefits.
The present study was designed to evaluate the influence of long term
administration of aspirin, either in low or high dose, on spermatogenesis,
reproductive hormones, and oxidant /antioxidant status of testicular tissue.
After one week of acclimatization, rats were weighed and randomly
allocated into 3 equal groups, each of 16 rats as illustrated in table (1).
group 1: Rats received 0.5 ml distilled water for 60 days.
group 2: Rats Received aspirin at dose of (5 mg kg-1 b.w.) orally twice daily
for 60 days.
group 3: Rats Received aspirin at dose of (125 mg kg-1 b.w..) orally twice daily
for 60 days.
Rats were fasted overnight. Five rats from each group were weighed then
sacrificed via jugular vein section under light ether anesthesia on 30 days and
60 days of experimental period. Then samples were taken to evaluate
hematological parameters, oxidant/antioxidant status, spermogram and
histopathological finding. And our results were as following:
VIII.Effect of aspirin on total body weight, body weight gain.
Oral administration of both doses of aspirin for 30 and 60 successive
days induce a significant decrease in body weight and body weight gain
compared with the control group.
IX.Effect of aspirin on hematological parameters.
Aspirin administration at different doses for 30 successive days induced
a non-significant decrease in RBCs count compared with the control group.
However, continuous administration of both doses of aspirin for successive 60.