الفهرس | Only 14 pages are availabe for public view |
Abstract The elimination of foreign compounds (xenobiotics) such as drugs and toxins from the body is an essential process designed to protect against potential toxicity. This process is mainly controlled by cytochrome P450 enzymes system (CYP-450s) that are responsible for the biological transformation and elimination of such xenobiotics, toxins and dietary constituents. These enzymes use haem iron to oxidise molecules, often making them more water-soluble for clearance. CYP450s constitute large super family of iron-containing proteins present primarily in liver cells as well as many other cell types, and participates mainly in hormone synthesis and breakdown including (estrogen, progesterone and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Many drugs may increase or decrease the activity of various CYP isozymes either by inducing the biosynthesis of an isozyme (enzyme induction) or by directly inhibiting the activity of the CYP (enzyme inhibition). This is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs. Therefore, this study was designed to pore over the effect of (dexamethasone) and (fluconazole) as CYP-450 inducer and inhibitor respectively, on the serum level of some endogenous steroidal hormones (cortisol, estrogen, progesterone and testosterone) that are mainly metabolized by CYPs. Furthermore, highlighting their reflection on the concerning parameters such as serum glucose, cholesterol and some electrolytes levels. In addition, investigating their effects on the exogenously administered testosterone H. |