الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The elimination of foreign compounds (xenobiotics) such as drugs
and toxins from the body is an essential process designed to protect against
potential toxicity. This process is mainly controlled by cytochrome P450
enzymes system (CYP-450s) that are responsible for the biological
transformation and elimination of such xenobiotics, toxins and dietary
constituents. These enzymes use haem iron to oxidise molecules, often
making them more water-soluble for clearance.
CYP450s constitute large super family of iron-containing proteins
present primarily in liver cells as well as many other cell types, and
participates mainly in hormone synthesis and breakdown including
(estrogen, progesterone and testosterone synthesis and metabolism),
cholesterol synthesis, and vitamin D metabolism.
Many drugs may increase or decrease the activity of various CYP
isozymes either by inducing the biosynthesis of an isozyme (enzyme
induction) or by directly inhibiting the activity of the CYP (enzyme
inhibition). This is a major source of adverse drug interactions, since changes
in CYP enzyme activity may affect the metabolism and clearance of various
drugs. Therefore, this study was designed to pore over the effect of
(dexamethasone) and (fluconazole) as CYP-450 inducer and inhibitor
respectively, on the serum level of some endogenous steroidal hormones
(cortisol, estrogen, progesterone and testosterone) that are mainly
metabolized by CYPs. Furthermore, highlighting their reflection on the
concerning parameters such as serum glucose, cholesterol and some
electrolytes levels. In addition, investigating their effects on the exogenously
administered testosterone H.