الفهرس | Only 14 pages are availabe for public view |
Abstract Dry eye is a disorder of the tear film that is caused by tear deficiency or excessive tear evaporation and this causes variable degrees of damage to the ocular surface . The current understanding of the pathogenesis of DES has proceeded from the mere recognition of a lack of , or altered quality of tears to recognition of inflammation as the key pathogenic mechanism, whether from a systemic autoimmune disease or a local autoimmune event. Clinical features of DES include an unstable tear film , ocular surface inflammation , and epitheliopathy, resulting in symptoms ranging from discomfort to blindness. An established sequence of diagnostic test is desirable to prevent one test from interfering with another. They include clinical diagnostic tests, histopathological tests, laboratory tests. Significant advances have been made in treating the many facets of dry eye, but it remains a disorder of long-term maintenance rather than permanent cure . Many years ago, the traditional approach to treat dry eye has been to lubricate the ocular surface by either replacing or conserving the patient’s tears . Tear supplementation is the first line of treatment, significant advances have been made for tear preservation . Corticosteroids, cyclosporine A have all been used with success to treat the secondry inflammatory response and consequential cellular changes of dry eye . |