الفهرس 
The Fetal Membranes andOnly 14 pages are availabe for public view
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Abstract
Objective: To evaluate the reliability of vaginal fluid urea and creatinine for the diagnosis of premature rupture of membranes.
Materials and Methods: 90 pregnant women were recruited. group I: 45 patients with confirmed PROM, group II: 45 normal pregnant women. All patients underwent ultrasonography, speculum examination for amniotic fluid pooling , nitrazine paper and vaginal washing fluid urea and creatinine sampling.
Results: The mean vaginal fluid urea levels in group I and II were 17.1 +/- 8.4 and 1.4 +/- 2.9 mg/dl, respectively, where the difference was statistically significant (P < 0.001). The sensitivity, specificity, positive predictivity, and negative predictivity were 97.8%, 91.1%, 91.7% and 97.6% in detecting PROM by evaluation of vaginal fluid urea with a cut-off value of >5 mg/dl. The mean vaginal fluid creatinine concentrations of group I and II were 1.13 +/- 0.93 , and 0.05 +/- 0.12 mg/dl (P < 0.001). The sensitivity, specificity, positive predictivity, and negative predictivity were 100%, 97.8%, 97.8% and 100% in detecting PROM by evaluation of vaginal fluid creatinine concentration with a cut-off value of >0.4 mg/dl.
Conclusion: Vaginal washing fluid urea and creatinine determination for the diagnosis of PROM is a reliable, simple and rapid test