الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 117 |  |  |
| | | from | 117 | | |
Abstract
Forty archival cases previously diagnosed as mucoepidermoid carcinomas will be included in this study .They were collected from archival files of Oral and General Pathology Departments, Faculties of Dentistry and Medicine, Mansoura University. Four micron sections were prepared for immunohistochemical staining with maspin antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results.
Results: In the present study, the mean age of patients was 48 years with slightly female predilection. The most commonly involved gland was parotid gland (55%). Stage III was the most common followed by stage IV (37.5% and 35 %) respectively. We found that high grade pattern was the most common (47.5%) followed by low grade one (35%). The least common was intermediate grade tumor which was only seen in seven cases (17.5%).
In the present work, 75% of MEC cases exhibited maspin immunoreactivity. Low-grade tumors predominantly showed mainly intense (42.85%) and moderate (42.85%) staining, whereas high-grade tumors showed mainly weak (36.84%) and negative (47.3%) staining.
Positive correlation was found between maspin expression and histological grades of MEC as well as its clinical stages.
Regarding AFIP parameters, inverse correlation was reported between intensity of maspin expression and mitosis while direct correlation was observed between maspin immunoreactivity and number of intracystic.
Regarding TNM clinical staging system, significant correlation between maspin expression and lymph node metastasis was found in this study.
Conclusions: Mucoepidermoid carcinoma express maspin with variable levels and cellular localization because it’s highly expressed in low grade malignancy, with progressive loss of its expression as histological grades raise. It might be considered as a potential immunohistochemical biomarker that could be used to evaluate the tumor progression and predict the prognosis of this type o f malignancy.