الفهرس 
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Abstract
The present thesis includes three main chapters with Arabic and English summaries as well as a list of references used in this study which
focus on synthesis and characterization of novel Pt(IV) complexes as
potential anticancer agents.
Chapter 1: - Introduction
This chapter contains an introduction about the coordination
chemistry of platinum, platinum(II) based anticancer drugs and
platinum(IV) prodrugs with a scientific literature survey on the Pt(IV)
complexes bearing biologically active axial ligands.
Chapter 2: - Materials and Methods
This chapter includes two main parts:
Experimental section
This section gives details of methods used for preparing novel Pt(IV)
complexes based on cisplatin, oxaliplatin and carboplatin in addition to the
Pt(II) complexes that bear indole acids as classical leaving groups. Spectral
methods (1H NMR, 195Pt NMR, IR and ESI-MS) and elemental analysis
were used for characterization of the structures of the ligands and their
Pt(IV) complexes. High performance liquid chromatography (HPLC)
technique was used to study the reduction reaction of the Pt(IV) complexes.
The cytotoxicity of the ligands and their complexes was evaluated with the
aid of MTT or XTT assay on a panel of human tumour cell lines.