الفهرس 
Chapter I : Childhood cancerOnly 14 pages are availabe for public view
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Abstract
Children successfully treated for cancer are often faced with a
unique set of health problems as they age because of the therapies
received in childhood. These chronic health problems may limit physical
performance, and, in turn, interfere with functional capacity and
participation in work, social, and recreational activities.
Iron overload is one of these problems which consider a significant cause
of morbidity and mortality for patients who require frequent transfusions
Iron accumulation in cancer patients receiving transfusions is
insidious, typically not monitored, and often goes unrecognized. The
most commonly encountered complications of iron overload include
endocrinopathies such as thyroid dysfunction, growth hormone
deficiency, diabetes, and delayed puberty although the most severe
toxicities are heart failure and hepatic insufficiency
We completed a prospective, cross-sectional study to evaluate the
prevalence of iron overload in previously transfused childhood cancer
survivors and prevalence of HFE gene among them. Mutation of HFE
gene alter Iron metabolism and may cause iron overload. Survivors
recruited from hematology and oncology department at El-Menoufia
University attending for long term follow up.
The objectives of this study were to determine:
To study the prevalence of the two HFE gene mutations in
Egyptian cancer survivors children and to evaluate the effect of these two
mutations on their iron status and also to evaluate the prevalence of iron
overload in previously transfused childhood cancer survivors.