الفهرس 
ObesityOnly 14 pages are availabe for public view
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Abstract
Shaimaa Hani Mohamed Fouad
M.B.,B.CH.,&MsC
Faculty of medicine-Ain shams university
Background and purpose
Globally, the number of obese individuals has reached alarming proportions. Several co morbidities are associated with this disease, especially immune dysfunction. Many studies demonstrated the negative impact of excess adiposity on immune function. Reports also indicate that a state of excess adiposity can increase the susceptibility to infections in both humans and mice.Studies reported considerable discrepancies in leucocyte number and subset counts and phagocytic and oxidative burst activity of monocytes between lean and obese individuals. The current study aims at investigating the cellular immune defense and T cell sub classes CD4& CD8amongapparently healthy obese subjects.
Methods A case control study was conducted on 30 adult obese (BMI ≥30) patients attending the outpatient Obesity clinic at Ain Shams University Hospitals between October 2014and February 2016.Twenty controls (BMI 18.5-24.9) with matched age and sex were also included. All patients provided an informed written consent. The study was approved by the University ethical committee. All participants were subjected to full detailed history, thorough clinical examination including Blood pressure, BMI, WC, Routine biochemical tests, CRP, -Flow cytometric analysis for cellular immunity (CD4- CD8) and serum leptin.
Results In all participants we found that age ,BMI, WC, and serum Leptin have positive correlations with CD4/CD8 ratio. In addition there was positive correlation between BMI, WC and CD4. On the other hand, the increase in serum TGs had negative correlation with CD4/CD8 ratio level and positive correlation with CD8 level.Diastolic blood pressure also had negative correlation with CD4, and CD4/CD8 ratio.While studying the obese group, we also found that there was positive correlation between age and CD4/CD8 ratio and negative correlation between Blood pressure and CD4 and CD4/CD8 ratio.On comparing obese and control groups we found that the obese group had statistically higher levels of monocytes, serum cholesterol level, LDL, serum Leptin, and CD4/CD8 ratio.
Conclusion There is no significantly negative effect of obesity on immune function.
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