الفهرس 
Gestational diabetesOnly 14 pages are availabe for public view
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Abstract
Introduction:
. Women who have had GDM are much more likely to develop type 2 DM later in life. Polyhydramnios, preterm labor, pyelonephritis, hypertension and preeclampsia were more frequent in GDM. Maternal hyperglycemia leads to intrauterine hyperglycemia, fetal hyper- insulinemia, shoulder dystocia, hyperbilirubinaemia, respiratory distress syndrome birth injuries, perinatal mortality, polycythaemia, caesarean delivery and congenital anomalies we use new method for screeninig of GDM Materials and Methods Cohort study, carried out in the period between March 2015 and April 2016. Pregnant women at first trimester (10-13wks) susceptible to diabetes mellitus attending Al-azhar University Hospital (Damietta) at department of Obstetrics and Gynecology.
. Results:The majority of females (80.9%) were from rural area.47.9% had primary education;66% of females were housewives;age ranged from 18 to 45 years with mean of 27.08±5.80 years. Females developed gestational diabetes mellitus were 31 cases (33.3%).There is strong association between high uric acid level in 1st trimestr and subsequent development of GDM in 3rd trimestr with R.R 4.1. The mean age of those who suffered from GDM was signifiecally hiegher than those who were free from it (29.25±5.65 vs 26.01±5.61 respectively).
Women with positive family history for hypertension and with past history of GDM suffered from GDM at a higher level than those with negative history and the difference was statisticaly significant.
Although those who had a positive family history of diabetes had a higher level of developing GDM , yet the relation didn’t reach the level of the of the statistically significant difference.
The BMI ranged from 22.20 to 72.20 with mean of 32.99±6.70 kg/m2; and there was significant obesity in positive GDM group when compared to negative GDM group (36.36±6.27 vs 31.33±6.08 respectively).
The serum uric acid ranged from 1.2 to 6.60 with a mean of 3.71±1.19 mg/dl; and there was a significant increase of uric acid conc in positive GDM group when compared to negative GDM group (4.48±0.84 vs 3.33±1.16 respectively).Conclusion Elevated first-trimester uric acid concentration was correlated with an increased risk of developing GDM. The risk of developing GDM was 4-fold higher if first-trimester uric acid was ≥ 4mg/dl.The mean BMI was significantly higher in women who developed GDM when compared to women who did not develop GDM[(36.36±6.27vs31.33±6.08 respectively).The mean age of those who suffered from GDM was signifiecally hiegher than those who were free from it (29.25±5.65 vs 26.01±5.61 respectively)