الفهرس 
Fungal allergic asthmaOnly 14 pages are availabe for public view
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Abstract
Introduction: Asthma is a heterogeneous chronic inflammatory respiratory disease characterized by overproduction of mucus and airway-wall remodeling that leads to bronchial hyperactivity and airway obstruction. Allergens and some pathogens have been implicated in the worsening of asthma, For many years, allergic asthma has been considered a T helper 2 (TH2)-biased disease, characterized by eosinophil infiltration and the production of the cytokines interleukin (IL)-4, IL-5, and IL-13. Subjects and Methods. This study was conducted on 40 asthmatic patients and 20 healthy control subjects. Patients were selected from the allergy and immunology outpatient clinic at Armed Forces Hospital, Alexandria during the period from November 20l4 to December 20l5, Results
The present study comprised three groups, group l included l8 asthmatics with positive skin prick test to fungi, group 2 included 22 asthmatics with positive skin test to other allergens and the control group included 20 healthy volunteers. All groups were matched in age and sex. Conclusion.We identified a subpopulation of CD177% neutrophils in peripheral blood of allergic asthmatic patients and healthy controls with statistically significant difference between both groups being higher in asthmatics (especially those with mild and moderate asthma). Therefore, we can conclude that this cell population might be contributing during the initial phase asthmatic disease and/or during disease progression but its role has not yet been established. Also it is not possible to define any relation between this cell subpopulation and fungal allergy or severity of asthma.