الفهرس 
Protein Energy WastingOnly 14 pages are availabe for public view
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Abstract
Background: International Society of Renal Nutrition and Metabolism (ISRNM) has recommended the term Protein-Energy Wasting (PEW) for loss of body protein mass and fuel reserves that may occur commonly in patients with chronic kidney disease (CKD). PEW is one of the strongest predictors of mortality in patients with CKD. Cachexia is a severe form of PEW. The proposed causes of PEW are multi-factorial and include nutritional and non-nutritional mechanisms. Aim: Detection of the prevalence of protein energy wasting in hemodialysis patients. Detection of the potential usefulness of the various nutritional-inflammatory markers and anthropometric measures in the diagnosis of PEW in CKD. Subjects and Methods: A cross-sectional study was undertaken on eighty hemodialysis (HD) patients (39 men and 41 women). Inclusion criteria were age 18–80 years, receiving HD treatment at least three times per week. The duration of the study was 3 months. Exclusion criteria at the entry of the study were age <18 years, comorbidities, medications, recent trauma or surgical intervention that might interfere with the nutritional status, and a life expectancy of <3 months. Results: Most of our PEW patients showed a mild degree of wasting, even though they all were clinically stable and had not experienced superimposed catabolic illnesses for at least 3 months before study enrollment. Wasted patients in our study showed lower anthropometric measurements. Interestingly. In the current study, PEW patients showed significant alteration of body water distribution and ECW than well nourished ones. In our study, six components of MIS showed statistically significant hazard ratios for first hospitalization.
Keywords: ISRNM: International Society of Renal Nutrition and Metabolism, PEW: Protein-Energy Wasting, CKD: chronic kidney disease, HD: hemodialysis.