الفهرس 
Pathophysiology of Diabetic RetinopathyOnly 14 pages are availabe for public view
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Abstract
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mi-togen in vitro and an angiogenic inducer in a variety of in vivo models.
Hypoxia has been shown to be a major inducer of VEGF gene transcription.
Anti-VEGF monoclonal antibodies and other VEGF inhibitors block the growth of several tumor cell lines.
So in our research we want to prove whether all patients with PDR have in-creased levels of VEGf and need Anti VEGF drugs treatment, and also show if the patients with non PDR have normal levels or increased VEGf concentra-tion.
To compare the concentration of VEG F in aqueos humor between pa-tients with proliferative and non proliferative diabetic retinopathy, hence show their need for anti VEG F drugs.
Our study included 70 eyes of 70 patients: 25 eyes with proliferative di-abetic retinopathy, 25 eyes with non proliferative diabetic retinopathy. And 20 eyes as control group with senile cataract that underwent cataract removal sur-gery. These patients was selected from ophthalmology outpatient clinic at Ain Shams University Hospital and from Rowad Correction Centre for Lasik and Eye Surgery.
Undiluted aqueous fluid samples were obtained from the patients undergo-ing intraocular surgery. All patients had undergone cataract surgery with phacoemulsification.
1.The aqueous levels of VEGF were significantly elevated in eyes with DR compared to normal eyes and also to NDR without clinically significant diabet-ic macular edema.
2.This elevation also correlated with the severity of DR, with a moderate in-crease of VEGF in the NPDR with clinically significant diabetic macular edema and a more pronounced increase in active PDR eyes; eyes with quiescent PDR had lower VEGF levels, comparable to the levels in PDR eyes.
3.NDR without clinically significant diabetic macular edema eyes had aqueous VEGF levels similar to those of normal control eyes.
keywords :
Diabetic Retinopathy , VEGF (Vascular endothelial growth factor) , Aqueous tapping , CME (Cystoid macular edema).