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العنوان
Synthesis of Some Five Membered Heterocylic Compounds Derivatives Incorporated of Quinazoline/
المؤلف
El-Rakhawy,Aya Elsayed Mohammed .
هيئة الاعداد
باحث / آيه السيد محمد الرخاوي
مشرف / فرج عبد الله العيسوي
مناقش / فرج عبد الله العيسوي
الموضوع
Chemistry. Heterocyclic compounds. Incorporated of Quniazoline.
تاريخ النشر
2016.
عدد الصفحات
91 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
4/9/2016
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Reaction of quinazoline with chloroacetonitril and potassium carbonate anhydrous in the presence of DMF was stirred for 13 h to afford2-[4-oxoquinazolin 3(4H)-yl]acetonitrile (2)in 70% yield
A solution of 2 and hydrazine hydrate in ethanol was reflux for 5 h to
afford 2-[4-Oxoquinazolin-3(4H)-yl]acetimidohydrazide (3)in 43.5% yield
A mixture of 2with sodium azide and ammonium chloride in the presence
of DMF was reflux for 7 h to afford
3-[(2H-tetrazol-5-yl)methyl]quinazolin-4(3H)-one (4)in 84.5% yield A mixture of 3 with triethyl ortho formate in ethanol was refluxed for 24 h to afford 3[(1H1,2,4triazol3yl)methyl]quinazolin-4(3H)-one (5)in 45 % yield