الفهرس 
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Abstract
This thesis describes the synthesis of new heterocyclic derivatives with an ultimate goal of
exploring new procedures for the synthesis. This co-supervise research was carried out under
the Channel Scheme between school of Pharmacy in Zagazig University and School of
Chemistry in Cardiff University.
Chapter one: this chapter contains an investigation for the application of Claisen
rearrangement in order to incorporate various carbon-based substituents into a 4-amino-3thioxo-1,2,4-triazine
nucleus
of
potential
pharmaceutical
interest.
In addition to the synthesis
of novel triazine-3,5(2H,4H)-dione derivatives via the application of high-yielding acidcatalysed
rearrangement
procedure.
Chapter
two: this chapter aimed to utilise the acid-catalysed hydroamination to synthesise
tetrahydroisoquinolines from suitably substituted benzhydryl derivatives. The used
methodology represents an alternative to the classical Pictet-Spengler synthesis of
tetrahydroisoquinolines. Chapter three: this chapter focus on extending the synthetic route used in chapter two to
provide phthalazine analogues by incorporating hydrazine functionalities rather than using
protected amines. Mitsunobu protocols were used successfully to deliver the targeted
hydrazine precursors.On the other hand, Suzuki coupling of the obtained precursors with
different boronic acids and ester allow the synthesis of a series of tri-substituted phthalazine
derivatives.
Chapter four: this chapter describes silver-catalysed cyclisations, it involves5-endo-dig
cyclizations of a small series of alkyne-diols derived from large carbocycles in order to
synthesize furan derivatives with macrocyclic structures that could be useful in the fragrance
industry.
Chapter Five: Contains the experimental section for the prepared compounds. It describes
the reactions in details in addition to interpretations for the obtained spectroscopic data.