الفهرس 
Hepatitis C Virus
Human immunodeficiency virus (HIV)Only 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) infection is a major health problem
worldwide. Egypt is the country with the highest HCV infection
epidemic in the world.
Although chronic HCV infections are often clinically silent for
decades, an estimated 85% of individuals infected with HCV develop
persistent infection, and these patients are likely to end up with
cirrhosis and liver cancer
Cell-mediated immunity is thought to play a critical role in viral
clearance and disease pathogenesis during HCV infection. Interleukin
(IL)-12 is a cytokine that has been shown to have a potent role as an
antiviral cytokine. The gene encoding IL-12 p40 is polymorphic and a
functional single nucleotide polymorphism (SNP) of the 3-untranslated
region rs3212227 at position 1188 A/C was associated with apparent
resistance to HCV.
The aim of this work was to study the association of IL-12 B
gene polymorphism with various stages of liver disease in HCV
infected patients.
One hundred and fifty persons were included in the study; these
persons were divided into five groups:
group (I): Included 30 chronic hepatitis C virus (HCV) patients.
group (II): Included 30 HCV patients with compensated cirrhosis.
group (III): Included 30 HCV patients with decompensated cirrhosis.
group (IV): Included 30 HCV patients complicated with HCC.