الفهرس 
Cisplatin and acute kidney injury (AKIOnly 14 pages are availabe for public view
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Abstract
Background and aim of the study: Acute kidney injury (AKI) is a syndrome of rapidly declining renal function. This study was conducted to evaluate the capability of BMSCs versus its conditioned medium in minimizing the cisplatin induced renal injury.
Methods: Sixty adult female albino rats were divided into 4 groups. group I (the control group), group II (cisplatin treated group), group III (stem cell treated group), group IV (conditioned medium treated group). Rats of all groups were sacrificed on 4th day of the experiment. Renal specimens were prepared for histological and immunohistochemical techniques. Morphometrical and statistical analysis were performed.
Results: Light microscopic examination revealed necrotic and apoptotic changes in renal tubules. Sloughing of epithelial lining of some tubules to the lumen of tubules with formation of acidophilic casts were detected. Fibrous tissue could be detected in the interstitium and lumen of some tubules. Injection of BMSCs resulted in improvement of renal structure. Injection of conditioned medium (CM) was less effective than BMSCs in treatment of AKI.
Conclusion: BMSCs injection is preferable than CM in the treatment of cisplatin induced AKI.
Keywords: Acute kidney injury, bone marrow-derived mesenchymal stem cells, conditioned medium