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Abstract Lymphatic filariasis (LF) is focally endemic in Egypt where the female mosquito, Culex pipiens, is responsible for its transmission. The aim of the study was to investigate the impact of implementation of 13thround of MDA in two Egyptian villages in Menoufyia governorate area after failing transmission assessment survey (TAS) in 2005.It also aimed at demonstrating the value of supplementation of molecular xenomonitoring (MX) technique to the immunochromatographic card test (ICT)when deciding whether to stop mass drug administration (MDA) in a locality. A cross-sectional study was carried out in the villages in 2014 with two sections. Section (1):a school based survey where all the primary school entrants (6-7) years of age were tested by ICT. Section (2): Mosquito based survey where a total of 152 mosquito pools collected from Samalay and 227 from Kafr El-Tarainah were tested for the presence of the gDNA of Wuchereria bancroftimicrofilaria by Real-time PCR assays. The results revealedthat all primary school children in both villages were 100% negative for antigenemia. Also, all mosquito pools were 100% negative for the microfilarial gDNA. Key words: LF, Wuchereria bancrofti, Culex pipiens, ICT, MDA, MX. |