الفهرس 
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Abstract
5-Fluorouracil (5-FU) has a wide anticancer activity versus several types of solid tumors. The activity of 5-FU can be improved and its toxicity can be diminished by enhancing the relative specific accumulation in the tumor regions. The aim of this work was to develop Eudragit RL 100 and RS100 based 5-FU microsponges (MS) for the treatment of colon cancer. Oil in oil emulsion solvent diffusion method was used for the preparation of 5-FU sustained releas MS. MS were characterized for their encapsulation efficiency, production yield, drug polymer interaction and drug release profiles. Shape, surface morphology visualized by scanning electron microscope (SEM) and particle size of MS was investigated using laser light scattering technique and. Eventually, HCT 116 and Caco-2 cell lines were used for determination of cell viability by MTT assay. After that the prepared 5-FU microsponges were enclosed in colon specific tablets to deliver the 5-FU specifically to the colon.