الفهرس 
TYPE 1 DIABETES MELLITUS
Epidemiology of type 1 Diabetes MellitusOnly 14 pages are availabe for public view
 |  | from | 189 |  |  |
| | | from | 189 | | |
Abstract
Type 1 diabetes mellitus (T1DM) is considered as the most
common metabolic childhood disease. Genetic variants
associated with type 1 diabetes mellitus provide either
susceptibility to or protection from the disease within a given
environmental background.
The aim of the current study was designed to assess level
of IVS1 −397T>C Estrogen Receptor α polymorphism and its
relation to level of FSH and LH in young girls with type 1
diabetes mellitus.
40 young regularly menstruating girls with type 1
diabetes mellitus were recruited from the Paediatric Diabetes
Clinic, Children’s hospital, Ain Shams University in the interval
from April, 2015 to November, 2015. Their age ranged 11.54 -
17.93 years with mean age 15.44 years.
All patients were subjected to a detailed medical history,
physical examination, anthropometric measurments, pubertal
assessment, investigation from previous follow up records (last
RBS, last FBS, mean FBS in the last 6 months, last HbA1C,
mean annual HbA1C and microalbuminuria), and
measurements of IVS1-397T>C estrogen receptor alpha
genotypes, FSH and LH.The patients were subdivided according to IVS1-397T>C
estrogen receptor alpha genotypes into 3 groups: CC, TC, and
TT group.
The study revealed:
There was no statistically significant difference between
IVS1-397T>C estrogen receptor alpha genotypes regarding
FSH (p=0.706) or LH (p=0.187).
The TC genotype was the most prevalent genotype in the
patients of the study.
There was significant difference between CC genotype
patients and TT genotype patients as regard the age being
higher in CC genotype patients.
The TT genotype patients had a younger age of onset of
T1DM, whereas patients with TC genotype had older age of
onset of T1DM.
The TT genotype patients had a longer T1DM duration than
CC and TC genotype patients.
The prevalence of obesity was less among CC genotype
patients than TC and TT genotype patients, and there was a
significant difference between CC genotype patients and TC
genotype patients as regard prevalence of obesity being
higher in TC genotype patients.The prevalence of systolic HTN was higher among TT
genotype patients than CC and TC genotype patients, while
the prevalence of diastolic HTN was higher among CC
genotype patients than TC and TT genotype patients.
The CC genotype patients had the best control of all
following parameters (last RBS, last FBS, mean FBS in last
6 months, last HbA1C, and mean annual HbA1C) when
compared to their TC and TT genotype bearing
counterparts.
The prevalence of microalbuminuria was less common
among CC genotype patients than TC and TT genotype
patients, without any significant difference between the
three groups.