الفهرس 
Morphologic approach to classification (FAB ClassificationOnly 14 pages are availabe for public view
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Abstract
Acute leukemias are clonal, neoplastic proliferation of immature cells of the hematopoietic system, which are characterized by aberrant or arrested differentiation with increase in the number of blast cells that have common characteristics which induce poor responsiveness to regulatory mechanisms (apoptosis) and tendency to have diminished capacity for normal differentiation and expansion at the expense of normal elements. In Egypt, the incidence of acute leukemia represents 6/ 100,000 per year
According to the blast cell type two acute leukemia variant had been recognized which include acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Acute lymphoblastic leukemia is malignant clonal disorder of the bone marrow lymphopoietic precursor cells with progressive medullary and extramedullary accumulation of lymphoblasts that lack the potential for differentiation and maturation.
The human WT1 gene is localized at chromosome 11p13 and spans about 50 kb. It encodes a mRNA about 3 kb long which contains 10 exons. Expression of WT1 in human cells of hematopoietic origin has suggested a role for WT1 in control of proliferation and/or differentiation of hematopoietic cells. characterization of its expression pattern indicate that WT1 is expressed in primitive immature cells
Acute leukemias are clonal, neoplastic proliferation of immature cells of the hematopoietic system, which are characterized by aberrant or arrested differentiation with increase in the number of blast cells that have common characteristics which induce poor responsiveness to regulatory mechanisms (apoptosis) and tendency to have diminished capacity for normal differentiation and expansion at the expense of normal elements. In Egypt, the incidence of acute leukemia represents 6/ 100,000 per year
According to the blast cell type two acute leukemia variant had been recognized which include acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Acute lymphoblastic leukemia is malignant clonal disorder of the bone marrow lymphopoietic precursor cells with progressive medullary and extramedullary accumulation of lymphoblasts that lack the potential for differentiation and maturation.
The human WT1 gene is localized at chromosome 11p13 and spans about 50 kb. It encodes a mRNA about 3 kb long which contains 10 exons. Expression of WT1 in human cells of hematopoietic origin has suggested a role for WT1 in control of proliferation and/or differentiation of hematopoietic cells. characterization of its expression pattern indicate that WT1 is expressed in primitive immature cells
Acute leukemias are clonal, neoplastic proliferation of immature cells of the hematopoietic system, which are characterized by aberrant or arrested differentiation with increase in the number of blast cells that have common characteristics which induce poor responsiveness to regulatory mechanisms (apoptosis) and tendency to have diminished capacity for normal differentiation and expansion at the expense of normal elements. In Egypt, the incidence of acute leukemia represents 6/ 100,000 per year
According to the blast cell type two acute leukemia variant had been recognized which include acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Acute lymphoblastic leukemia is malignant clonal disorder of the bone marrow lymphopoietic precursor cells with progressive medullary and extramedullary accumulation of lymphoblasts that lack the potential for differentiation and maturation.
The human WT1 gene is localized at chromosome 11p13 and spans about 50 kb. It encodes a mRNA about 3 kb long which contains 10 exons. Expression of WT1 in human cells of hematopoietic origin has suggested a role for WT1 in control of proliferation and/or differentiation of hematopoietic cells. characterization of its expression pattern indicate that WT1 is expressed in primitive immature cells
Acute leukemias are clonal, neoplastic proliferation of immature cells of the hematopoietic system, which are characterized by aberrant or arrested differentiation with increase in the number of blast cells that have common characteristics which induce poor responsiveness to regulatory mechanisms (apoptosis) and tendency to have diminished capacity for normal differentiation and expansion at the expense of normal elements. In Egypt, the incidence of acute leukemia represents 6/ 100,000 per year
According to the blast cell type two acute leukemia variant had been recognized which include acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Acute lymphoblastic leukemia is malignant clonal disorder of the bone marrow lymphopoietic precursor cells with progressive medullary and extramedullary accumulation of lymphoblasts that lack the potential for differentiation and maturation.
The human WT1 gene is localized at chromosome 11p13 and spans about 50 kb. It encodes a mRNA about 3 kb long which contains 10 exons. Expression of WT1 in human cells of hematopoietic origin has suggested a role for WT1 in control of proliferation and/or differentiation of hematopoietic cells. characterization of its expression pattern indicate that WT1 is expressed in primitive immature cells