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Abstract This study was conducted during the period from September 2014 to November 2015 at Al-Warraq abattoir and Berqash camel trading market, Giza (Egypt). Out of the 850 Al-Warraq abattoir examined animals, 88(10.35%) camels were affected by CLA. The disease appeared clinically as superficial abscesses which varied in size from lemon to orange size or even larger containing pus of different colors and consistency. Visceral lesions were rare and only represented 0.58% of examined animals. Corynebacterium pseudotuberculosis, C. jeikeium, C. urealyticum, Cellulomonas spp. /Microbacterium spp., Brevibacterium spp. and other gram positive cocci are associated with CLA in camels. Serological testing revealed a high seropositivity among the examined imported camels (82.7%); seropositivity percentage was reported to be 58.06% for exotoxin ELISA and 61.29% for SWC ELISA. In addition, Bovine γ-IFN assay has no value to diagnose CLA in camels. Finally, Histopathological examination of the affected LNs revealed suppuration, necrosis, hyperplastic lymphoid follicles and sinus histocytosis. |