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Abstract This study was conducted to detect the effect of HBB on the first stage of labor. The study included 110 primigravid women who were randomized into two groups; group 1 (Study group) which included pregnant women who received prefilled 2 ml Hyoscine butylbromide (40 mg) via IMI. group 2 (Control group) which included pregnant women who received prefilled 2 ml normal saline via IMI. The study protocol was approved by the ethical committee of Faculty of Medicine, Menoufia University and an informed consent was obtained from all participants prior to the beginning of the study. All participants were subjected to full medical and obstetric history and examination with partographic follow up throughout the labor. No significant statistical difference between the two groups as regarding the demographic features (maternal age, body mass index, gestational age, maternal disease, hemoglobin concentration and occupation). There was highly significant statistical difference between both groups as regarding duration from admission till full cervical dilation, duration from admission till delivery and rate of cervical dilation. In the study group, the duration of the first stage was 208.16 min and cervical dilatation rate was 1.71cm/hr. While in the control group The duration of the first stage was 258.16 min and cervical dilatation rate was 1.05cm/hr But, there was no significant statistical difference between both groups as regarding augmentation of labor, duration of second stage of labor, duration of third stage of labor and mode of delivery. No cases of postpartum hemorrhage in both groups No significant statistical difference between both groups as regarding the adverse effect of HBB. No significant statistical difference between both groups as regard CTG changes, APGAR score at 1 and 5 minutes, NICU admission and neonatal weight. |