الفهرس 
Immunopathogenesis of PsoriasisOnly 14 pages are availabe for public view
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Abstract
Background: Psoriasis is a chronic inflammatory papulosquamous disease characterized by multiple remission and relapses. Although the definite aetiopathogenesis of psoriasis remains unclear, many different mechanisms may contribute to the pathogenesis of psoriasis. Interleukin (IL)-36γ is a newly described member of the IL-1 family cytokine . IL-36 γ plays a role in the inflammatory and pathogenic cascade of psoriasis. Furthermore ,IL-36γ activates MAP kinase of NFκB signaling with subsequent expression and production of pro-inflammatory cytokines.
Objectives: To investigate the presence of IL36γ in the sera of patients with different types of psoriasis in order to assess its possible role in the pathogenesis of the disease and its correlation with disease activity.
Patients and Methods: This study included 60 patients with psoriasis (20 with plaque, 20 with pustular and 20 with erythrodermic) and 20 healthy subjects who served as control group. Blood samples were taken from all patients and control to determine serum IL-36 γ level, which was measured by enzyme linked immunosorbant assay (ELISA). The relationship between IL-36 γ and the psoriasis area and severity index (PASI) score was investigated in psoriatic patients.
Results: Serum IL-36 γ levels were significantly higher in psoriatic patients compared with healthy controls. There was highly significant correlation was found between serum IL-36γ and age of patients and duration of the disease. IL-36γ levels were directly correlated with the activity of the disease based on PASI score. There was also a highly significant increase in IL-36γ in erythrodermic psoriatic patients compared to other types. There was a relative significant difference between plaque and pustular as regards IL-36 γ which was higher in pustular type.
Conclusion: Interleukin 36 γ protein may play a role in the pathogenesis of psoriasis. Serum Interleukin 36 γ can be used as an indicator for the activity of the disease.