الفهرس | Only 14 pages are availabe for public view |
Abstract Bisphenol-A (BPA) is used in manufacture of the resin that lines most food cans, polycarbonate plastics and dental sealants. It has been reported that humans get exposed to BPA after release and hydrolysis of its monomer from the containers into liquid or food. BPA was claimed to induce histological alteration in the testes of different species including human due to its estrogenic activity as it can mimic the action of natural estrogen in the testis. Aim of the work: The aim of this study was to detect the possible protective effect of pomegranate juice on bisphenol-A treated albino rats using some cytogenetic and histological techniques. Material & Methods: The present study was carried out on 60 adult male albino rats that were divided into two main groups, control and experimental groups. Control group (group I) included 30 rats which were subdivided into three equal subgroups: Negative control (Subgroup Ia) that were kept without treatment throughout the whole period of the experiment, vehicle control (Subgroup Ib) that were given corn oil, the solvent of Bisphenol-A at a dose 5 ml/kg once daily by gastric tube for 8 weeks and pomegranate control (Subgroup Ic) that received pomegranate juice in a dose of 3 ml/kg once daily by gastric tube for 8 weeks. |