الفهرس 
PreeclampsiaOnly 14 pages are availabe for public view
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Abstract
Preeclampsia, a human-pregnancy-specific disease defined as the occurrence of hypertension and significant proteinuria in a previously healthy woman on or after the 20th week of gestation, occurs in about 2-8% of pregnancies.
Preeclampsia is a rapidly progressive condition characterized by high blood pressure, platelet aggregation, swelling of the lower extremities and protein in urine. It is the most common medical complication of pregnancy whose incidence has continued to increase worldwide, and it is associated with significant maternal morbidity and mortality, accounting for about 50,000 deaths worldwide annually.
Risk factors for preeclampsia include nulliparity (not bearing offspring), multifetal gestations, previous history of preeclampsia, obesity, diabetes mellitus, vascular and connective tissue disorders like systemic lupus erythematosus and antiphospholipid antibodies, age >35 years at first pregnancy, smoking, and African American race .
Although its pathogenesis remains an enigma, it is nevertheless widely accepted that the abnormality in this disorder lies in the placenta, as the disease usually abates soon after the delivery of the placenta.
The present study was conducted on specific placental biomarkers at delivery, in an attempt to elucidate the underlying mechanism for the pathogenesis of PE in Egyptian women. These included prostate specific antigen (PSA), 17-β estradiol (E2), interleukin-6 (IL-6), oxidative stress and some minerals. To fulfill the target of the present study, fifty women at delivery were included; twenty five women with preeclampsia and twenty five gestational age matched pregnant women with normal blood pressure.
The placenta was collected after delivery and kept until analysis. Parameters included full blood pressure, liver function, blood sugar, prostate specific antigen (PSA), estradiol (17β Estradiol), interleukin 6 (IL6), oxidative stress (MDA and GPx) and metals (Zn, Cu and Ca) in placental tissue.
The results of the present study are summarized as follows:
• Significant difference in the systolic blood pressure (p<0.001), diastolic blood pressure (p<0.001), albuminuria (p<0.001), platelets (p<0.049), hemoglobin (p< 0.014), placental PSA (p<0.002), IL6 (p<0.05) and estradiol (p<0.012) in preeclamptic women compared with normotensive pregnant women.
• No significant difference in placental MDA, GPx and trace metals (Zn, Cu and Ca), between both groups was recorded.
• Correlations between chosen markers revealed that the increase in placental PSA was accompanied by a decrease in placental 17-β estradiol (p<0.001) and IL-6 (p<0.005), as well as platelet (p<0.025) levels.
• The decrease of placental estradiol was inversely correlated with diastolic blood pressure, albuminuria, and placental PSA, and was positively correlated with platelets and placental IL-6.