الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 158 |  |  |
| | | from | 158 | | |
Abstract
The hydrazones and their transition metal complexes have been well documented in the literature as good antimicrobial, anticonvulsant, anticancer, antibacterial and antitumor agents as well as antiviral. The current interest in hydrazones is due to the presence of various donor atoms (N, O and OH-donors), which exhibit diverse bonding modes leading to different structural motifs. New ligand was prepared and used in this study namely, 2-(2-(2-hydroxybenzyliden)hydrazinyl)-2-oxo-N-(pyridine-2-yl)acetamide (H2L) The preparation of this ligand (H2L), and its metal complexes with different transition metals salt of Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and U(VI)O2 Were described. Elemental analyses, thermal (TG and DTG), spectral (IR, 1H,13C NMR, UV-visible, MS), and magnetic measurements were used to characterize the isolated solid complexes. Also, computational studies for all compounds were done. Moreover, pH-matric technique, and biological activity as antimicrobial , antifungal and DNA-binding were carried out. In general, three types of solid complexes were isolated in which the ligand behaved in neutral, mononegative and /or binegative manner. The electronic spectra and magnetic measurements for the isolated complexes indicated that all complexes had octahedral structure. Computational studies for all compounds were carried out to confirm the geometry of the isolated complexes. Thermal decomposition of some solid complexes under an atmosphere of nitrogen was investigated. Moreover, biological activity (Antifungal, antimicrobial and DNA-binding) for the ligand and its metal complexes under investigation were carried out. The result showed that [Ni(L)(H2O)2].2H2O complex had higher biological activity than the other synthesized compound Finally, Cobalt(II) and copper(II) complexes of H2L has been studied pH-metrically. The titrations were performed at ionic strength of µ=0.05 M KCl and at 298, 308 and 318oK.